Growth Hormone Deficiency (GHD)


The prevalence of GHD is approximately 1/5,000 1 in children and approximately 2-3 per 10,000 2 in adults 

Growth Hormone Deficiency is not just about height, growth hormone supports overall endocrine health 3-10.


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Appropriate growth hormone replacement therapy is the conventional treatment for growth hormone deficiency.



  • The primary objectives of GH treatment for patients with GHD in children are acceleration of growth velocity to promote normalization of growth and stature during childhood and attainment of normal AH appropriate for the child’s genetic potential 11 .

  • For adult patients, the main goal of treatment is to reverse the adverse metabolic consequences of hormone deficiency and improve QoL 2 .


Growth hormone therapy is a long-term process. Short-acting growth hormone needs to be injected subcutaneously once per day, which may result in poor adherence , high treatment burden, and failure to achieve expected treatment goal. One study has shown that as the number of missed injections per week increases, the growth improvement decreases12 (as illustrated in bellowing figure).

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Long-acting growth hormone can reduce injection frequency, which is expected to improve patient compliance,  potential longer persistence and better outcomes13.


Reference

1. Ranke MB, et al. Nat Rev Endocrinol. 2018;14(5):285-300.

2. Yuen KCJ, et al. Endocr Pract. 2019;25(11):1191-1232.

3. de Boer H, et al. J Clin Endocrinol Metab. 1997;82(7):2032–2036.

4. Rutherford OM, et al. Clin Endocrinol (Oxf). 1991;34(6):469–475.

5. Colle M, et al. Horm Res. 1993;39(5-6):192-6.

6. Johannsson G, et al. J Endocrinol Invest. 1999;22(5 Suppl):41-6.

7. Stabler B, et al. Anxiety. 1996;2(2):86–89.

8. Leong GM, et al. Horm Res. 2003;60(Suppl 1):78–85.

9. Colao A, et al. J Clin Endocrinol Metab. 2002 Aug;87(8):3650-5.

10. Bex M, et al. Horm Res. 2003;60 Suppl 3:80–86.

11. Grimberg A, et al. Horm Res Paediatr. 2016;86(6):361-397.

12. Cutfield WS,et al. PLoS One. 2011;6(1):e16223.

13. Lal RA, et al. Pediatr Endocrinol Rev. 2018 Sep;16(Suppl 1):162-167.